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oxMIF Biology

A Disease-Restricted Target for Precision Therapeutics.

Our founders discovered that in inflamed tissues and solid tumors, oxidative conditions convert the ubiquitously expressed cytokine Macrophage Migration Inhibitory Factor (MIF) into a distinct disease-restricted isoform: oxMIF

What Makes oxMIF Unique.

In its oxidized form, MIF adopts a more flexible structure, exposing epitopes that are hidden in native MIF. Unlike its precursor, oxMIF is selectively present at sites of inflammation and cancer, and absent from healthy tissue making it a highly specific, disease-restricted target.

What Makes oxMIF Unique.

In its oxidized form, MIF adopts a more flexible structure, exposing epitopes that are hidden in native MIF. Unlike its precursor, oxMIF is selectively present at sites of inflammation and cancer, and absent from healthy tissue making it a highly specific, disease-restricted target.

Why This Matters.

The selective presence of oxMIF at disease sites enables the development of therapeutics that act precisely where needed. This site-restricted targeting approach has the potential to improve selectivity, reduce off-target effects, and support a favorable safety profile without interfering with the physiological functions of native MIF.

Technology Platform Anti-oxMIF

What Can Be Built on It.

The oxMIF biology supports a broad range of therapeutic and diagnostic approaches, including:
Highly selective antibody-based therapeutics and

Highly selective antibody-based therapeutics and

Radioimmunoconjugates for diagnostic imaging of active inflammation and solid tumors

Radioimmunoconjugates for diagnostic imaging of active inflammation and solid tumors

Combination strategies across oncology and inflammatory disease

Combination strategies across oncology and inflammatory disease

ImmunoOne's proprietary oxMIF platform integrates advanced antibody engineering expertise with disease-restricted targeting, enabling highly selective therapeutic approaches in cancer and chronic inflammation.

OncoOne's oxMIF

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